The Edge made history yesterday as the first rock musician to perform in the Sistine Chapel, Reuters reports. The U2 guitarist, whose father died of cancer last month and whose daughter overcame leukemia, played a short acoustic set for a crowd of about 200 doctors, researchers, and philanthropists gathered for Cellular Horizons, a conference on regenerative medicine and cancer treatment held at the Vatican over the weekend. “When they asked me if I wanted to become the first contemporary artist to play in the Sistine Chapel, I didn’t know what to say because usually there’s this other guy [in U2] who sings,” he joked during the performance. Watch him play a cover of Leonard Cohen’s “If It Be Your Will” backed by a choir of seven Irish teenagers below.