Pearl Jam’s Eddie Vedder recently appeared in a video to shed some light on epidermolysis bullosa, a debilitating skin condition. “When I first heard about it, it was quite hard to grasp the intensity of the condition. It’s about the most insane skin disorder you can imagine,” Vedder said. “And when you realize it also affects the internal organs, then you see it as diabolical.” Vedder sits on the board of the EB Research Partnership, which is fundraising money to help research the prevention of the condition through genetic editing. Watch the video below.